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mwawYY1 (mwbaYin Yang 1)cite-ref-1[1] è una mwcqproteina mwcgtrascrizionale presente nell'uomo,cite-ref-2[2] codificata dal mwdwgene YY1, che agisce sia come mwearepressore che come attivatore, da cui il nome "Yin-Yang".cite-ref-pmid1655281-3-0[3]cite-ref-pmid7912122-4-0[4]

• Funzioni

• Rilevanza clinica

• Interazioni

• Note

• Bibliografia

• Collegamenti esterni

YY1 è un mwhafattore di trascrizione ubiquitario appartenente alla famiglia delle proteine a dita di zinco. La proteina è coinvolta nella repressione e nell'attivazione di un numero diversificato di promotori. Pertanto, la sigla YY nel nome sta per “mwhqyin-yang”. YY1 può indirizzare le istone deacetilasi e le mwhwistone acetiltransferasi verso un promotore al fine di attivarlo o reprimerlo, implicando così la modificazione degli mwiaistoni nella funzione di YY1.cite-ref-5[5]

Y1 promuove gli anelli mwjgcromatinici mwjwenhancer-mwkapromotore formando mwkqdimeri e favorendo le interazioni del DNA. La sua disregolazione interrompe i loop enhancer-promotore e l'mwkgespressione genica.cite-ref-6[6]cite-ref-yy1-haploinsufficiency-causes-an-intellectual-disability-syndrome-featuring-transcriptional-and-chromatin-dysfunction-7-0[7] YY1 può legare complessi di istone deacetilasi (HDAC), che rimuovono i gruppi acetilici dai residui di mwmwlisina degli istoni, favorendo una conformazione della cromatina "chiusa" e inattiva.

Le mwngdelezioni mwnweterozigoti, le mwoamutazioni missenso e nonsense del gene YY1 causano la sindrome di Gabriele-DeVries (GADEVS),cite-ref-8[8]cite-ref-9[9] disturbo dello sviluppo neurologico autosomico dominante caratterizzato da disabilità intellettiva, caratteristiche facciali dismorfiche, problemi di alimentazione, ritardo della crescita intrauterina, deficit cognitivo variabile, problemi comportamentali e altre malformazioni congenite.cite-ref-yy1-haploinsufficiency-causes-an-intellectual-disability-syndrome-featuring-transcriptional-and-chromatin-dysfunction-7-1[7]

È disponibile un sito web per raccogliere e condividere informazioni cliniche tra medici e famiglie delle persone affette dalla malattia.cite-ref-10[10]

Sono state dimostrate le seguenti mwtqinterazioni della YY1:

• mwuaATF6,cite-ref-pmid10866666-11-0[11]

• EP300cite-ref-pmid11486036-12-0[12]cite-ref-pmid7758944-13-0[13]

• FKBP3cite-ref-pmid11532945-14-0[14]

• mwzgHDAC3cite-ref-pmid11486036-12-1[12]cite-ref-pmid9346952-15-0[15]

• istoene deacitalasi 2cite-ref-pmid11486036-12-2[12]cite-ref-pmid9346952-15-1[15]cite-ref-pmid9016636-16-0[16]

• mwfgMyccite-ref-pmid8266081-17-0[17]

• NOTCH1cite-ref-pmid12913000-18-0[18]

• RYBPcite-ref-pmid10369680-19-0[19] and

• SAP30cite-ref-huang-20-0[20]

• Serina—tRNA ligasicite-ref-fu-21-0[21]

cite-note-11. ↑ mwoqThiaville MM, Kim J, mwogmwowOncogenic potential of yin yang 1 mediated through control of imprinted genes, in mwpaCritical Reviews in Oncogenesis, vol.mwpq 16, 3–4, 2011, pp.mwpg 199–209, mwpwDOI:mwqa10.1615/critrevoncog.v16.i3-4.40, mwqqPMCmwqg mwqw3392609, mwraPMIDmwrq mwrg22248054.

cite-note-22. ↑ mwsgFattore di trascrizione YY1

cite-note-pmid1655281-33. ↑ mwtgShi Y, Seto E, Chang LS, Shenk T, mwtwmwuaTranscriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein, in mwuqCell, vol.mwug 67, n.mwuw 2, Oct 1991, pp.mwva 377–88, mwvqDOI:mwvg10.1016/0092-8674(91)90189-6, mwvwPMIDmwwa mwwq1655281.

cite-note-pmid7912122-44. ↑ mwxqZhu W, Lossie AC, Camper SA, Gumucio DL, mwxgmwxwChromosomal localization of the transcription factor YY1 in the mouse and human, in mwyaMammalian Genome, vol.mwyq 5, n.mwyg 4, Apr 1994, pp.mwyw 234–6, mwzaDOI:mwzq10.1007/BF00360552, mwzgPMIDmwzw mw0a7912122, mw0qhdl:mw0g2027.42/47010.

cite-note-55. ↑ mw1gmw1wmw2aEntrez Gene: YY1 YY1 transcription factor, su mw2qncbi.nlm.nih.gov.

cite-note-66. ↑ mw3qWeintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA, mw3gmw3wYY1 Is a Structural Regulator of Enhancer-Promoter Loops, in mw4aCell, vol.mw4q 171, n.mw4g 7, dicembre 2017, pp.mw4w 1573–1588. e28, mw5aDOI:mw5q10.1016/j.cell.2017.11.008, mw5gPMCmw5w mw6a5785279, mw6qPMIDmw6g mw6w29224777.

cite-note-yy1-haploinsufficiency-causes-an-intellectual-disability-syndrome-featuring-transcriptional-and-chromatin-dysfunction-77. ↑ mw8qGabriele M, Vulto-van Silfhout AT, Germain PL, Vitriolo A, Kumar R, Douglas E, Haan E, Kosaki K, Takenouchi T, Rauch A, Steindl K, Frengen E, Misceo D, Pedurupillay CR, Stromme P, Rosenfeld JA, Shao Y, Craigen WJ, Schaaf CP, Rodriguez-Buritica D, Farach L, Friedman J, Thulin P, McLean SD, Nugent KM, Morton J, Nicholl J, Andrieux J, Stray-Pedersen A, Chambon P, Patrier S, Lynch SA, Kjaergaard S, Tørring PM, Brasch-Andersen C, Ronan A, van Haeringen A, Anderson PJ, Powis Z, Brunner HG, Pfundt R, Schuurs-Hoeijmakers JH, van Bon BW, Lelieveld S, Gilissen C, Nillesen WM, Vissers LE, Gecz J, Koolen DA, Testa G, de Vries BB, mw8gmw8wYY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction, in mw9aAmerican Journal of Human Genetics, vol.mw9q 100, n.mw9g 6, giugno 2017, pp.mw9w 907–925, mw-aDOI:mw-q10.1016/j.ajhg.2017.05.006, mw-gPMCmw-w mw-a5473733, mw-qPMIDmw-g mw-w28575647.

cite-note-88. ↑ mwaqmmwaqqmwaquGabriele-de Vries Syndrome, in mwaqyOMIM.

cite-note-99. ↑ mwaqoNabais Sá MJ, Gabriele M, Testa G, de Vries BB, mwaqsGabriele-de Vries Syndrome, in mwaqwGeneReviews [Internet]., Seattle (WA), University of Washington, Seattle, 1993, mwaq0PMIDmwaq4 mwaq831145572.

cite-note-1010. ↑ mwarmmwarqmwaruYY1 – Collect information about clinic management and research projects, su mwaryYY1.

cite-note-pmid10866666-1111. ↑ mwaroLi M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS, mwarsmwarwATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1, in mwar0Molecular and Cellular Biology, vol.mwar4 20, n.mwar8 14, Jul 2000, pp.mwasa 5096–106, mwaseDOI:mwasi10.1128/mcb.20.14.5096-5106.2000, mwasmPMCmwasq mwasu85959, mwasyPMIDmwasc mwasg10866666.

cite-note-pmid11486036-1212. ↑ mwataYao YL, Yang WM, Seto E, mwatemwatiRegulation of transcription factor YY1 by acetylation and deacetylation, in mwatmMolecular and Cellular Biology, vol.mwatq 21, n.mwatu 17, Sep 2001, pp.mwaty 5979–91, mwatcDOI:mwatg10.1128/mcb.21.17.5979-5991.2001, mwatkPMCmwato mwats87316, mwatwPMIDmwat0 mwat411486036.

cite-note-pmid7758944-1313. ↑ mwauiLee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y, mwaummwauqRelief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300, in mwauuGenes & Development, vol.mwauy 9, n.mwauc 10, maggio 1995, pp.mwaug 1188–98, mwaukDOI:mwauo10.1101/gad.9.10.1188, mwausPMIDmwauw mwau07758944.

cite-note-pmid11532945-1414. ↑ mwaveYang WM, Yao YL, Seto E, mwavimwavmThe FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1, in mwavqThe EMBO Journal, vol.mwavu 20, n.mwavy 17, Sep 2001, pp.mwavc 4814–25, mwavgDOI:mwavk10.1093/emboj/20.17.4814, mwavoPMCmwavs mwavw125595, mwav0PMIDmwav4 mwav811532945.

cite-note-pmid9346952-1515. ↑ mwawuYang WM, Yao YL, Sun JM, Davie JR, Seto E, mwawymwawcIsolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family, in mwawgThe Journal of Biological Chemistry, vol.mwawk 272, n.mwawo 44, Oct 1997, pp.mwaws 28001–7, mwawwDOI:mwaw010.1074/jbc.272.44.28001, mwaw4PMIDmwaw8 mwaxa9346952.

cite-note-pmid9016636-1616. ↑ mwaxqKalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC, mwaxumwaxyYeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1, in mwaxcNucleic Acids Research, vol.mwaxg 25, n.mwaxk 4, Feb 1997, pp.mwaxo 843–9, mwaxsDOI:mwaxw10.1093/nar/25.4.843, mwax0PMCmwax4 mwax8146511, mwayaPMIDmwaye mwayi9016636.

cite-note-pmid8266081-1717. ↑ mwayyShrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K, mwaycmwaygInhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc, in mwaykScience, vol.mwayo 262, n.mways 5141, Dec 1993, pp.mwayw 1889–92, mway0Bibcode:mway41993Sci...262.1889S, mway8DOI:mwaza10.1126/science.8266081, mwazePMIDmwazi mwazm8266081.

cite-note-pmid12913000-1818. ↑ mwazcYeh TS, Lin YM, Hsieh RH, Tseng MJ, mwazgmwazkAssociation of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch, in mwazoThe Journal of Biological Chemistry, vol.mwazs 278, n.mwazw 43, Oct 2003, pp.mwaz0 41963–9, mwaz4DOI:mwaz810.1074/jbc.M304353200, mwaaaPMIDmwaae mwaai12913000.

cite-note-pmid10369680-1919. ↑ mwaayGarcía E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M, mwaacmwaagRYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1, in mwaakThe EMBO Journal, vol.mwaao 18, n.mwaas 12, Jun 1999, pp.mwaaw 3404–18, mwaa0DOI:mwaa410.1093/emboj/18.12.3404, mwaa8PMCmwaba mwabe1171420, mwabiPMIDmwabm mwabq10369680.

cite-note-huang-2020. ↑ mwabgHuang NE, Lin CH, Lin YS, Yu WC, mwabkmwaboModulation of YY1 activity by SAP30, in mwabsBiochemical and Biophysical Research Communications, vol.mwabw 306, n.mwab0 1, Jun 2003, pp.mwab4 267–75, mwab8Bibcode:mwaca2003BBRC..306..267H, mwaceDOI:mwaci10.1016/s0006-291x(03)00966-5, mwacmPMIDmwacq mwacu12788099.

cite-note-fu-2121. ↑ mwackFu CY, Wang P, Tsai HJ, mwacomwacsCompetitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis, in mwacwNucleic Acids Research, vol.mwac0 45, n.mwac4 5, Nov 2017, pp.mwac8 2423–2437, mwadaDOI:mwade10.1093/nar/gkw1187, mwadiPMCmwadm mwadq5389716, mwaduPMIDmwady mwadc27913726.

• mwadsThomas MJ, Seto E, Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?, in Gene, vol. 236, n. 2, Aug 1999, pp. 197–208, DOI:10.1016/S0378-1119(99)00261-9, PMID 10452940.

• mwad0Park K, Atchison ML, Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site, in Proceedings of the National Academy of Sciences of the United States of America, vol. 88, n. 21, Nov 1991, pp. 9804–8, Bibcode:1991PNAS...88.9804P, DOI:10.1073/pnas.88.21.9804, PMC 52809, PMID 1946405.

• mwad8Yang WM, Inouye CJ, Seto E, Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity, in The Journal of Biological Chemistry, vol. 270, n. 25, Jun 1995, pp. 15187–93, DOI:10.1074/jbc.270.25.15187, PMID 7541038.

• mwaeeLee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y, Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300, in Genes & Development, vol. 9, n. 10, maggio 1995, pp. 1188–98, DOI:10.1101/gad.9.10.1188, PMID 7758944.

• mwaemZhou Q, Gedrich RW, Engel DA, Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB, in Journal of Virology, vol. 69, n. 7, Jul 1995, pp. 4323–30, DOI:10.1128/JVI.69.7.4323-4330.1995, PMC 189172, PMID 7769693.

• mwaeuShrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K, Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc, in Science, vol. 262, n. 5141, Dec 1993, pp. 1889–92, Bibcode:1993Sci...262.1889S, DOI:10.1126/science.8266081, PMID 8266081.

• mwaecBecker KG, Swergold GD, Ozato K, Thayer RE, Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element, in Human Molecular Genetics, vol. 2, n. 10, Oct 1993, pp. 1697–702, DOI:10.1093/hmg/2.10.1697, PMID 8268924.

• mwaekMargolis DM, Somasundaran M, Green MR, Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production, in Journal of Virology, vol. 68, n. 2, Feb 1994, pp. 905–10, DOI:10.1128/JVI.68.2.905-910.1994, PMC 236527, PMID 8289393.

• mwaesLee JS, Galvin KM, Shi Y, Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1, in Proceedings of the National Academy of Sciences of the United States of America, vol. 90, n. 13, Jul 1993, pp. 6145–9, Bibcode:1993PNAS...90.6145L, DOI:10.1073/pnas.90.13.6145, PMC 46884, PMID 8327494.

• mwae0Yang WM, Inouye C, Zeng Y, Bearss D, Seto E, Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3, in Proceedings of the National Academy of Sciences of the United States of America, vol. 93, n. 23, Nov 1996, pp. 12845–50, Bibcode:1996PNAS...9312845Y, DOI:10.1073/pnas.93.23.12845, PMC 24008, PMID 8917507.

• mwae8Houbaviy HB, Usheva A, Shenk T, Burley SK, Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator, in Proceedings of the National Academy of Sciences of the United States of America, vol. 93, n. 24, Nov 1996, pp. 13577–82, Bibcode:1996PNAS...9313577H, DOI:10.1073/pnas.93.24.13577, PMC 19349, PMID 8942976.

• mwafeKalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC, Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1, in Nucleic Acids Research, vol. 25, n. 4, Feb 1997, pp. 843–9, DOI:10.1093/nar/25.4.843, PMC 146511, PMID 9016636.

• mwafmCole EG, Gaston K, A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors, in Nucleic Acids Research, vol. 25, n. 18, Sep 1997, pp. 3705–11, DOI:10.1093/nar/25.18.3705, PMC 146936, PMID 9278494.

• mwafuYang WM, Yao YL, Sun JM, Davie JR, Seto E, Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family, in The Journal of Biological Chemistry, vol. 272, n. 44, Oct 1997, pp. 28001–7, DOI:10.1074/jbc.272.44.28001, PMID 9346952.

• mwafcRomerio F, Gabriel MN, Margolis DM, Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF, in Journal of Virology, vol. 71, n. 12, Dec 1997, pp. 9375–82, DOI:10.1128/JVI.71.12.9375-9382.1997, PMC 230241, PMID 9371597.

• mwafkMcNeil S, Guo B, Stein JL, Lian JB, Bushmeyer S, Seto E, Atchison ML, Penman S, van Wijnen AJ, Stein GS, Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking, in Journal of Cellular Biochemistry, vol. 68, n. 4, Mar 1998, pp. 500–10, DOI:10.1002/(SICI)1097-4644(19980315)68:4<500::AID-JCB9>3.0.CO;2-U, PMID 9493912.

• mwafsViles JH, Patel SU, Mitchell JB, Moody CM, Justice DE, Uppenbrink J, Doyle PM, Harris CJ, Sadler PJ, Thornton JM, Design, synthesis and structure of a zinc finger with an artificial beta-turn, in Journal of Molecular Biology, vol. 279, n. 4, Jun 1998, pp. 973–86, DOI:10.1006/jmbi.1998.1764, PMID 9642075.

• mwaf0Yao YL, Dupont BR, Ghosh S, Fang Y, Leach RJ, Seto E, Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1, in Nucleic Acids Research, vol. 26, n. 16, Aug 1998, pp. 3776–83, DOI:10.1093/nar/26.16.3776, PMC 147783, PMID 9685495.

• mwageYY1

• mwagmP25490 -Transcriptional repressor protein YY1, PDBe-KB